@Russ PLEX has a nice system, whereby you can tell Alexa to run on a specific PC, or you can set a default that it will run all commands on unless otherwise specified, you could do something like:
"Alexa, ask TRIGGERcmd to Set Default PC"
"Which PC would you like to set as your default?
"Default PC set to TV"
"Alexa, ask TRIGGERcmd to run Notepad"
"Running Notepad on TV"
"Alexa, ask TRIGGERcmd to run Notepad on Work"
"Running Notepad on Work"